Elderly people with dementia-related psychosis (a severe mental health problem) taking atypical antipsychotic drugs, including SAPHRIS, are at an increased risk for death compared with those taking placebo (sugar tablet). SAPHRIS is not approved for the treatment of people with dementia-related psychosis (see Boxed Warning). Continued below
My health matters to me.

Staying on treatment

Taking SAPHRIS every day

Taking SAPHRIS every day can help you manage the symptoms of schizophrenia. Because it can be hard to remember to take your medicine, you may want to:
  • Create a routine that you follow every day
  • Ask your family members or friends to call, text, or e-mail you each day to remind you to take your medicine. You can e-mail this page to them to ask for help
  • Place your SAPHRIS sublingual tablets near your bed so you see them. Keep SAPHRIS out of the reach of children

The following is a sample plan for taking SAPHRIS.

When talking with
your healthcare provider
You may want to ask:
  • When should I take SAPHRIS?
  • How can I remember to take SAPHRIS every day?
  • Can I eat or drink after taking SAPHRIS?
Print a list of questions to ask your healthcare provider.


SAPHRIS—Savings and coverage
Savings coupon—Eligible patients may save up to $20 off on each of up to 6 qualifying prescriptions for SAPHRIS. Not all patients are eligible. Please see Terms & Conditions. Learn more about the savings coupon.

Insurance coverage—Most people with insurance coverage have access to SAPHRIS with no restrictions. This includes people who have private insurance or Medicaid. Contact your insurance company to learn about your coverage for SAPHRIS. You can also talk with your healthcare provider.

A sample plan for taking SAPHRIS 2 times a day, every day


Wake up and take SAPHRIS.Take SAPHRIS.
Do NOT eat or drink for 10 minutes after taking SAPHRIS. Do NOT eat or drink for 10 minutes after taking SAPHRIS.
Eat breakfast and get ready for your day.Get ready for bed as you usually do.

Create your own plan for taking SAPHRIS

Work with your healthcare provider to create a plan for taking SAPHRIS that is right for you. Write down tips that will help you remember to take SAPHRIS. Be sure to take SAPHRIS  every day. Learn more about how to take SAPHRIS.


Keeping track of your progress

Keep track of how you are doing. Use the online progress tracker at the start of your treatment with SAPHRIS and during your treatment, especially before each visit with your healthcare provider. Set up reminders to go to your office visits. Share your completed tracker with your healthcare provider.


SAPHRIS is a type of medicine called an atypical antipsychotic. It is approved for the treatment of schizophrenia in adults.

Important Safety Information

Elderly people with dementia-related psychosis (a severe mental health problem) taking atypical antipsychotic drugs, including SAPHRIS, are at an increased risk for death compared with those taking placebo (sugar tablet). SAPHRIS is not approved for the treatment of people with dementia-related psychosis (see Boxed Warning). An increased risk for stroke and ministroke has been reported in elderly people with dementia-related psychosis.

Serious allergic reaction: Do not take SAPHRIS if you are allergic to any of its ingredients. Seek immediate emergency assistance if you have symptoms of a serious allergic reaction, such as difficulty breathing; itching; swelling of the face, tongue, or throat; or light-headedness.

Neuroleptic malignant syndrome (NMS): Tell your healthcare provider right away if you have high fever; stiff muscles; confusion; changes in pulse, heart rate, or blood pressure; sweating; or muscle pain and weakness. These can be signs of a rare and potentially fatal side effect (NMS) that has been reported with SAPHRIS and similar medicines. Treatment should be stopped if you have NMS.

Also tell your healthcare provider if:
  • You have or had low white blood cell counts, because low white blood cell counts and related conditions have been reported with SAPHRIS and similar medicines
  • You have certain heart conditions such as irregular heartbeats, or take certain medicines that can cause irregular heartbeats, because SAPHRIS should be avoided in these circumstances
  • You have a seizure disorder, have had seizures, or have conditions that increase your risk for seizures
  • You are taking or plan to take prescription and over-the-counter medicines, because there is a risk for drug interactions with SAPHRIS
  • You have thoughts of suicide or of hurting yourself or others. Symptoms of bipolar I disorder or schizophrenia may include these thoughts. If you have these thoughts at any time, tell your healthcare provider or go to an emergency room right away
  • You have or have had swallowing problems, because SAPHRIS and medicines like it have been associated with swallowing problems
  • You experience a lack of menstrual periods, leaking or enlarged breasts, or impotence, because SAPHRIS and medicines like it may raise the levels of prolactin. The levels may continue to be high when SAPHRIS is used over time
  • You are pregnant or planning to get pregnant while taking SAPHRIS

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Please click here for Prescribing Information, including the Boxed Warning about increased risk of death in elderly people with dementia-related psychosis (a severe mental health problem), and discuss it with your healthcare provider.

This site is intended only for residents of the United States, its territories, and Puerto Rico.

SAPHRIS is a registered trademark of N.V. Organon, a subsidiary of Merck & Co., Inc.

Copyright © 2013 MSD Oss B.V., a subsidiary of Merck & Co., Inc. All rights reserved.
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